Both positive and negative experiences influence how genetic variants affect the brain and thereby behaviour, according to a new study. "Evidence is accumulating to show that the effects of variants of many genes that are common in the population depend on environmental factors. Further, these genetic variants affect each other," explained Sheilagh Hodgins of the University of Montreal and its affiliated Institut Universitaire en Santé Mentale de Montréal. "We conducted a study to determine whether juvenile offending was associated with interactions between three common genetic variants and positive and negative experiences." Hodgins and her colleagues published the study on December 11, 2014 in the International Journal of Neuropsychopharmacology.